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Results Effects of cuprizone feed formulation on body weight Following 3 weeks on diets of control powder, cuprizone-containing powder, control pellet or cuprizone-containing pellet, mice were assessed for weight loss, a widely recognised hallmark of cuprizone intoxication 34

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The Nrf2 pathway is therefore activated by both compounds — but MC1R is the upstream activator for MT-2 whereas GHK-Cu activates Nrf2 directly without melanocortin receptor mediation